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UID:DSC-15725
DTSTART;TZID=Europe/Berlin:20190401T110000
SEQUENCE:1554163735
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20190401T120000
URL:https://www.dresden-science-calendar.de/calendar/en/detail/15725
LOCATION:MPI-CBG\, Pfotenhauerstraße 10801307 Dresden
SUMMARY:Liu: \"Bottom-up Synthetic Biology and a Foray into Phase Separatio
 n\"
CLASS:PUBLIC
DESCRIPTION:Speaker: Allen Liu\nInstitute of Speaker: University of Michiga
 n\nTopics:\nBiologie\n Location:\n  Name: MPI-CBG (MPI-CBG Seminar Room 3r
 d Floor)\n  Street: Pfotenhauerstraße 108\n  City: 01307 Dresden\n  Phone
 : +49 351 210-0\n  Fax: +49 351 210-2000\nDescription: Cells are made up o
 f compartments that are delimited by membranes or by protein- and/or nucle
 ic acid-rich liquid phases. Significant amount of work has elucidated the 
 molecular machineries that regulate dynamic membrane-based processes and t
 here is growing appreciation of membrane-less organelles in cell biology. 
 In parallel\, there are growing interests in recent years in trying to und
 erstand how mechanical state of the cells are utilized as a regulatory inp
 ut to control cellular processes. My lab is broadly interested in studying
  the mechanochemical responses of biological membrane. In particular\, as 
 part of our bottom-up synthetic biology effort\, we are building artificia
 l cells that can sense mechanical input and transduce a biochemical respon
 se. To this end\, we are attempting to build artificial platelets that mim
 ic the functionalities of natural platelets. I will discuss several modula
 r platforms that we have developed that together will integrate into funct
 ional artificial cells. In the second part of my talk\, I will discuss the
  potential for using liquid-liquid phase separation as a paradigm for spat
 ially organizing reactions within artificial cells. I will describe some r
 ecent work on characterizing diffusion of small molecules within and outsi
 de of phase-separated coacervate droplets. Our growing capability to compa
 rtmentalize biology within membrane or membraneless compartments will enab
 le us to build increasingly complex cell-like systems.
DTSTAMP:20260806T221629Z
CREATED:20190301T000754Z
LAST-MODIFIED:20190402T000855Z
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