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UID:DSC-15711
DTSTART;TZID=Europe/Berlin:20190305T130000
SEQUENCE:1551744421
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URL:https://www.dresden-science-calendar.de/calendar/en/detail/15711
LOCATION:IFW\, Helmholtzstraße 2001069 Dresden
SUMMARY:Aziz: Towards imaging of medical microbots
CLASS:PUBLIC
DESCRIPTION:Speaker: Azaam Aziz\nInstitute of Speaker: IFW Dresden\nTopics:
 \nMaterialien\, Physik\n Location:\n  Name: IFW (B3E.26\, Leibniz IFW Dres
 den)\n  Street: Helmholtzstraße 20\n  City: 01069 Dresden\n  Phone: \n  F
 ax: \nDescription: Miniature technologies\, like medical microbots\, could
  revolutionize many fields of medicine by enabling non-invasive diagnosis\
 , drug-delivery and therapeutic procedures. As explained recently by our r
 esearch group\, microbots must clear two major hurdles to enter clinical t
 rials: visualization and control inside the body [1].  Researchers are try
 ing to improve microbot imaging strategies to achieve better resolution an
 d sensitivity. For example\, Bradley et al. demonstrated controlled swimmi
 ng of a swarm of around 10.000 artificial bacterial flagella (ABFs) in a m
 ouse using fluorescence imaging [2]. Sarthak et al. could track the trajec
 tory of a trail of bubbles from fast-moving microjets using ultrasound in 
 a water batch containing hydrogen peroxide [3]\, and Martel et al. reporte
 d the visualization of a cluster of magnetotactic bacteria (5X107 bacteria
 l count per mL) using magnetic resonance imaging (MRI) in a 1.5 mL Progene
  microtube [4]. So far\, different imaging techniques have been explored b
 ut they are still too coarse for single-microbot imaging. In radiology\, n
 uclear medicine and X-rays employ hazardous radiation and contrast agents.
  Likewise\, MRI can resolve structures with submillimeter resolution and i
 n some cases offering temporal resolutions in the milliseconds range but d
 emands expensive infrastructure and continuous presence of strong magnetic
  fields.  To overcome some of these limitations\, we explored the use of t
 wo types of optical imaging techniques. First\, we developed a customized 
 infrared imaging (IR) setup which operates in the first biological window 
 to visualize mobile microstructures under phantom tissues using the princi
 ple of light reflection. The technique shows advantages such as the possib
 ility to resolve microstructures down to 20 µm in diameter and their real
  time tracking under phantom tissues\, without using any labels. The secon
 d optical approach combines the advantages of ultrasound such as penetrati
 on depth and real-time imaging with the molecular specificity of optical t
 echniques\, also called optoacoustic imaging. This technique was used to t
 rack conical microtubes with 100 µm length in three dimensions and in rea
 l time. With this technique we lose spatial resolution but gain on penetra
 tion depth This achievement is of great importance for the visualization o
 f dynamic processes that occur at the microscale\, and in particular\, for
  the tracking and control of emerging technologies such as medical microbo
 ts\, micro-catheters and in general of small medical tools.  [1] M. Medina
 -Sánchez and O. G. Schmidt\, Nature\, vol. 545\, no. 7655\, pp. 406–408
 \, (2017) [2] A. Servant et al.\, Adv. Mater.\, vol. 27\, no. 19\, pp. 298
 1–2988\, (2015) [3] A. Sánchez et al.\, Proc. IEEE RAS EMBS Int. Conf. 
 Biomed. Robot. Biomechatronics\, pp. 169–174\, (2014) [4] O. Felfoul et 
 al.\, Annu. Int. Conf. IEEE Eng. Med. Biol. Soc. EMBC’10\, vol. 1\, pp. 
 4367–4370\, (2010)
DTSTAMP:20260511T121339Z
CREATED:20190227T000742Z
LAST-MODIFIED:20190305T000701Z
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