BEGIN:VCALENDAR
VERSION:2.0
PRODID:www.dresden-science-calendar.de
METHOD:PUBLISH
CALSCALE:GREGORIAN
X-MICROSOFT-CALSCALE:GREGORIAN
X-WR-TIMEZONE:Europe/Berlin
BEGIN:VTIMEZONE
TZID:Europe/Berlin
X-LIC-LOCATION:Europe/Berlin
BEGIN:DAYLIGHT
TZNAME:CEST
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
DTSTART:19810329T030000
RRULE:FREQ=YEARLY;INTERVAL=1;BYMONTH=3;BYDAY=-1SU
END:DAYLIGHT
BEGIN:STANDARD
TZNAME:CET
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
DTSTART:19961027T030000
RRULE:FREQ=YEARLY;INTERVAL=1;BYMONTH=10;BYDAY=-1SU
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
UID:DSC-15658
DTSTART;TZID=Europe/Berlin:20190314T160000
SEQUENCE:1552522138
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20190314T170000
URL:https://www.dresden-science-calendar.de/calendar/en/detail/15658
LOCATION:TUD CRTD\, Fetscherstraße 10501307 Dresden
SUMMARY:Haass: Function and dysfunction of microglia in neurodegenerative d
 isorders
CLASS:PUBLIC
DESCRIPTION:Speaker: Prof. Christian Haass\, Ludwig-Maximilians-University 
 & German Center for Neurodegenerative Diseases\, Munich\nInstitute of Spea
 ker: DZNE\nTopics:\nBiologie\, Medizin\n Location:\n  Name: TUD CRTD (CRTD
 \, auditorium)\n  Street: Fetscherstraße 105\n  City: 01307 Dresden\n  Ph
 one: +49 (0)351 458 82052\n  Fax: +49 (0)351 458 82059 \nDescription: Abst
 ractWe demonstrate that amyloid plaque seeding is increased in the absence
  of functional TREM2. Increased seeding is accompanied by decreased microg
 lial clustering around newly seeded plaques and reduced plaque associated 
 Apolipoprotein E (ApoE). Reduced ApoE deposition in plaques is also observ
 ed in brains of AD patients carrying TREM2 coding variants. Proteomic anal
 yses and microglia depletion experiments revealed a microglial origin of p
 laque associated ApoE. Longitudinal amyloid small animal positron emission
  tomography demonstrates accelerated amyloidogenesis in TREM2 loss of func
 tion mutants at early stages\, which progressed at a lower rate with aging
 . These findings suggest that in the absence of functional TREM2 early amy
 loidogenesis is accelerated due to reduced phagocytic clearance of amyloid
  seeds despite reduced plaque associated ApoE. The 5 most important public
 ationsParhizkar S\, Arzberger T\, Brendel M\, Kleinberger G\, Deussing M\,
  Focke C\, Nuscher B\, Xiong M\, Ghasemigharagoz A\, Katzmarski N\, Krasem
 ann S\, Lichtenthaler SF\, Müller SA\, Colombo A\, Sebastian Monasor L\, 
 Tahirovic S\, Willem M\, Pettkus N\, Butovsky O\, Bartenstein P\, Edbauer 
 D\, Rominger A\, Ertürk A\, Jucker M\, Holtzman DM\, Meyer-Luehmann M\, H
 aass C. Loss of TREM2 function increases amyloid seeding but reduces plaqu
 e associated ApoE. Nature Neuroscience\, 22(2): 191-204. Suárez-Calvet M\
 , Caballero MA\, Kleinberger G\, Bateman RJ\, Fagan AM\, Morris JC\, Levin
  J\, Danek A\, Ewers M\, Haass C for the Dominantly Inherited Alzheimer Ne
 twork (2016) Early changes of CSF sTREM2 in Dominantly Inherited Alzheimer
 's Disease follow markers of Amyloid Deposition and Neuronal Injury. Scien
 ce Translational Medicine 8(369): 369ra178. Willem M\, Tahirovic S\, Busch
 e MA\, Ovsepian SV\, Chafai M\, Kootar S\, Hornburg D\, Evans LD\, Moore S
 \, Daria A\, Hampel H\, Muller V\, Giudici C\, Nuscher B\, Wenninger-Weinz
 ierl A\, Kremmer E\, Heneka MT\, Thal DR\, Giedraitis V\, Lannfelt L\, Mul
 ler U\, Livesey FJ\, Meissner F\, Herms J\, Konnerth A\, Marie H\, Haass C
  (2015) eta-Secretase processing of APP inhibits neuronal activity in the 
 hippocampus. Nature 526 :443-7. Kleinberger G.\, Yamanishi Y.\, Suárez-Ca
 lvet M.\, Czirr E.\, Lohmann E.\, Cuyvers E.\, Struyfs H.\, Pettkus N.\, W
 enninger-Weinzierl A.\, Mazaheri F.\, Tahirovic S.\, Lleó A.\, Alcolea D.
 \, Fortea J.\, Willem M.\, Lammich S.\, Molinuevo J. L.\, Sanchez-Valle R.
 \, Antonell A.\, Ramirez A.\, Heneka M.\, Sleegers K.\, van der Zee J.\, M
 artin J.-J.\, Engelborghs S.\, Demirtas-Tatlidede A.\, Zetterberg H.\, Van
  Broeckhoven C.\, Gurvit H.\, Wyss-Coray T.\, Hardy J.\, Colonna M. &amp\;
  Haass C. (2014) TREM2 mutations linked to neurodegeneration impair cell s
 urface transport and phagocytosis. Science Translational Medicine\, 6\, 1-
 29. Willem\, M.\, Garratt\, A.N.\, Novak\, B.\, Citron\, M.\, Kaufmann\, S
 .\, Rittger\, A.\, DeStrooper\, B.\, Saftig\, P.\, Birchmeier\, C. and Haa
 ss\, C. (2006) Control of peripheral nerve myelination by the beta-secreta
 se BACE1. Science 314\, 664-6.
DTSTAMP:20260421T030343Z
CREATED:20190209T000743Z
LAST-MODIFIED:20190314T000858Z
END:VEVENT
END:VCALENDAR