Precise genome engineering to empower drug discovery

Date

Jan 18, 2019

Time

3:00 PM - 4:00 PM

Speaker

Marcello Maresca

Affiliation

AstraZeneca Research Gothenburg, Sweden

Language

en

Main Topic

Biologie

Other Topics

Biologie, Medizin

Host

Prof. Dr. Francis Stewart

Description

InformationGene and base editing hold great promises in the prevention and treatment of genetic diseases. Predicting the on-target and off-target activities of Cas9/CRISPR and Base Editors is an essential requirement for a safe and efficacious treatment. Recent progress shows how the analysis and modulation of DNA repair pathway can be applied to predict base and genome editing outcomes. Taheri-Ghahfarokhi, Amir, et al. Decoding non-random mutational signatures at Cas9 targeted sites. Nucleic acids research 46.16 (2018): 8417-8434.Akcakaya, Pinar, et al. In vivo CRISPR editing with no detectable genome-wide off-target mutations. Nature 561.7723 (2018): 416.Wienert, Beeke, et al. Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq. bioRxiv (2018): 469635.

Links

• to announcement of the organizer

Last modified: Jan 18, 2019, 1:09:40 AM