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UID:DSC-14919
DTSTART;TZID=Europe/Berlin:20180906T160000
SEQUENCE:1536192335
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20180906T170000
URL:https://www.dresden-science-calendar.de/calendar/en/detail/14919
LOCATION:TUD CRTD\, Fetscherstraße 10501307 Dresden
SUMMARY:Encinas: Mechanisms Controlling the Induction of Reactive Neural St
 em Cells in the Hippocampus
CLASS:PUBLIC
DESCRIPTION:Speaker: Prof. Juan Manuel Encinas\nInstitute of Speaker: Achuc
 arro Basque Center for Neuroscience\, Laboratory of Neural Stem Cells and 
 Neurogenesis\nTopics:\nBiologie\, Medizin\n Location:\n  Name: TUD CRTD (C
 RTD\, ground floor\, auditorium left)\n  Street: Fetscherstraße 105\n  Ci
 ty: 01307 Dresden\n  Phone: +49 (0)351 458 82052\n  Fax: +49 (0)351 458 82
 059 \nDescription: Abstract  My research focuses on the intrinsic properti
 es of the neural stem cells in the adult mammal hippocampus. Their populat
 ion size\, rate of activation and mitotic potential\; their activation-cou
 pled astrocytic differentiation and entry into a senescence with aging...a
 ll these characteristics determine the true neurogenic potential of each i
 ndividual organism. Neurological disorders\, especially those associated w
 ith neuronal hyperactivation\, such as epilepsy\, profoundly affect neural
  stem cell properties affecting neurogenesis. For instance\, after seizure
 s\, neural stem cells transform into reactive astrocytes abandoning their 
 neurogenic program\, an unexpected phenomenon which mechanisms we are curr
 ently investigating.  5 most important publications Sierra A\, Martín-Su
 árez S\, Valcárcel-Martín R\, Pascual-Brazo J\, Aelvoet SA\, Abiega O\,
  Deudero JJ\, Brewster AL\, Bernales I\, Anderson AE\, Baekelandt V\, Male
 tić-Savatić M\, Encinas JM. Neuronal hyperactivity accelerates depletion
  of neural stem cells and impairs hippocampal neurogenesis. Cell Stem Cell
 . 2015 May 7\;16(5):488-503. Encinas JM\, Michurina TV\, Peunova N\, Park 
 JH\, Tordo J\, Peterson DA\, Fishell G\, Koulakov A\, Enikolopov G. Divisi
 on-coupled astrocytic differentiation and age-related depletion of neural 
 stem cells in the adult hippocampus. Cell Stem Cell. 2011 May 6\;8(5):566-
 79. Sierra A\, Encinas JM\, Deudero JJ\, Chancey JH\, Enikolopov G\, Overs
 treet-Wadiche LS\, Tsirka SE\, Maletic-Savatic M. Microglia shape adult hi
 ppocampal neurogenesis through apoptosis-coupled phagocytosis. Cell Stem C
 ell. 2010 Oct 8\;7(4):483-95. Eisch AJ\, Cameron HA\, Encinas JM\, Meltzer
  LA\, Ming GL\, Overstreet-Wadiche LS. Adult neurogenesis\, mental health\
 , and mental illness: hope or hype? J Neurosci. 2008 Nov 12\;28(46):11785-
 91 Encinas JM\, Vaahtokari A\, Enikolopov G. Fluoxetine targets early prog
 enitor cells in the adult brain. Proc Natl Acad Sci U S A. 2006 May 23\;10
 3(21):8233-8.
DTSTAMP:20260430T194714Z
CREATED:20180824T000638Z
LAST-MODIFIED:20180906T000535Z
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