Upconversion Super Dots for Super-Resolution Imaging and Single Molecule Tracking

Date

May 4, 2018

Time

1:00 PM - 2:00 PM

Speaker

Dist. Prof. Dayong Jin

Affiliation

University of Technology Sydney, Australia

Language

en

Main Topic

Materialien

Other Topics

Materialien, Physik

Host

Kristina Krummer

Description

Advances in super-resolution fluorescence imaging have enabled revolutionary new insight in the spatial and temporal behaviour of the cell. These developments have resulted in a need for the development of robust probes to facilitate long-term tracking of single molecules and real-time super-resolution imaging of sub-cellular structures. In my lecture, I will first showcase several new nanotechnology approaches to super-resolution imaging by leveraging optical-switching properties of new classes of luminescent nanoparticles, unlocking new modes of super-resolution microscopy with much higher photon yields than are currently available. I will then summarize our recent achievements by engineering time-resolved photonics devices and reagents to find cells earlier, quicker and with better resolution. These include the discovery of the Super Dots for single molecule detection and point-of-care diagnostics (Nature Nanotechnology 2013), demonstration of a time-domain multiplexing technology for high throughput biotechnology discoveries (Nature Photonics; Nature Communication 2014), creation of the large library of contrast agents for multi-functional bio-imaging and nanomedicine (Nature Communications 2016), invention of a low-power high contrast super resolution microscopy by achieving the highest optical resolution of 1/36 of the excitation wavelength (Nature 2017), the new discovery of thermal phonon enhanced upconversion Thermal Dots (Nature Photonics 2018), and our new development of a microscopy technique, aimed at improving the resolution and sensitivity of nanoscale imaging, leading to direct tracking of a single molecule inside a living cell by eye (Light: Science & Applications 2018). Our Key Papers [1] Zhao J, et al, Nature Nanotechnology, 8, 729-734 (2013), [2] Lu Y, et al, Nature Communications, 5, 3741 (2014), [3] Lu Y, et al, Nature Photonics, 8, 32-36 (2014), [4] Zhou B, et al, Nature Nanotechnology, 10 (11), 924-936 (2015) [4] Liu D, et al, Nature Communications, doi:10.1038/ncomms10254 (2016), [5] Liu Y, et al, Nature, 543 (7644), 229 (2017) [6] Wang F, et al, Light: Science & Applications, doi: 10.1038/lsa.2018.7 (2018) [7] Zhou J, et al, Nature Photonics, 12 (3), 154 (2018) [8] Jin D, et al, Nature Methods, in press (2018) [9] Wen S, et al, Nature Communications, in press (2018) [10] Lin G, et al, Chem, DOI: https://doi.org/10.1016/j.chempr.2018.01.009 (2018)

Links

• Seminars at the IFW

Last modified: May 4, 2018, 9:43:31 AM