Computational & Dimensional Psychiatry Approaches to Investigate Decision-Making in Disorders of Compulsivity and their Risk Factors
- Date
- Jun 29, 2017
- Time
- 4:00 PM - 5:00 PM
- Speaker
- Dr. Andrea Reiter
- Affiliation
- TU Dresden, Professur für Entwicklungspsychologie und Neurowissenschaft der Lebensspanne
- Series
- TUD NIC Kolloquium
- Language
- en
- Main Topic
- Psychologie
- Other Topics
- Psychologie
- Description
- Maladaptive decision-making is a core characteristic of many psychiatric disorders, with addiction and eating disorders as prominent examples. Within the larger agenda of computational psychiatry, models of decision-making could potentially have strong clinical impact: first, improving differential diagnosis by addressing clinical heterogeneity within and across symptom-based diagnoses; second, enhancing outcome prediction and thereby enabling specific treatment allocation. In a series of studies, we investigated decision-making based on two recently developing research paradigms: (1) Dimensional Psychiatry: First, we asked whether risk factors for addiction in healthy individuals (impulsivity, family history, stress) are accompanied by similar reductions in flexible goal-directed control as in patients. Second, flexible goal-directed decision-making of alcohol-dependent patients was investigated compared to healthy controls and the same study design was extended towards patients suffering from Binge Eating Disorder, a so-called “addiction-like” disorder characterized by the loss of control over eating behavior. (2) Computational Psychiatry: all presented work involves Reinforcement Learning modeling of behavior, also in combination with functional neuroimaging. I would like to discuss further possible avenues for fine-graining our understanding of disrupted decision-making in compulsive disorders, as well as implications of the results for the definition of biologically-informed patient subgroups and for the guidance of prevention and treatment strategies.
- Links
Last modified: Jun 16, 2017, 4:32:55 PM
Location
TUD Falkenbrunnen (FAL 157, Chemnitzer Str. 46b)01187Dresden
Organizer
Neuroimaging CentreChemnitzer Str.46a01187Dresden
- Phone
- +49 351 463 42063
- Fax
- +49 351 463 42438
- NIC
- Homepage
- http://www.nic-tud.de
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