Hematopoietic stem cell decline driven by stress-induced DNA damage

Date

Jan 28, 2016

Time

2:30 PM - 3:30 PM

Speaker

Michael Milsom

Affiliation

DKFZ Heidelberg

Series

IMB - Seminar

Language

en

Main Topic

Biologie

Other Topics

Biologie

Host

IMB

Description

Dr. Milsom's main research focus for the past 15 years has been the study of hematopoietic stem cell (HSC) biology, predominantly within the murine model of hematopoiesis but also employing human cell lines and primary patient material. He has extensively worked on understanding how DNA damage can impact on HSC function. This has led to his current interest in the ageing of the hematopoietic system, since DNA damage within the HSC compartment is likely one of the major effectors of age-associated decline in hematopoietic function and the related increased incidence in hematologic malignancy. This seminar will cover his group¹s recent work which explores infection and inflammation-associated stress-hematopoiesis as a potential physiologic source of DNA damage in HSCs, as recently published by his group in Nature (Walter et al., Nature, 2015).

Last modified: Jan 19, 2016, 8:08:45 PM