Srgap3-/- and Tsc2+/- animal models of schizophrenia and autism: implications for neuroscience and psychiatry

Date

Dec 17, 2015

Time

4:00 PM - 5:00 PM

Speaker

Dr. Robert Waltereit

Affiliation

Department of Child and Adolescent Psychiatry and Psychotherapy, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden

Language

en

Main Topic

Biologie

Other Topics

Biologie, Medizin

Host

Prof. Gerd Kempermann

Description

About the research of Dr. Waltereit: Many diseases in child and adolescent psychiatry are neurodevelopmental disorders – autism spectrum disorder, ADHD, intelligence deficiency and schizophrenia. The neurodevelopmental disturbances are expression of the underlying neurobiological pathomechanisms. Our goal is to study global and social cognition in the context of these diseases, using molecular and behavioural methods, focusing on animal models. We try to contribute to better understanding of the pathophysiology of these diseases and the development of experimental therapies. Publications: (1) Plath N, Ohana O, Dammermann B, Errington ME, Gross C, Mao X, Engelsberg A, Mahlke C, Welzl H, Kobalz U, Stawrakakis A, Fernandez E, Waltereit R, Bick-Sander A, Therstappen E, Cooke SF, Blanquet V, Wurst W, Salmen B, Bosl M, Lipp HP, Schmitz D, Grant SGN, Bliss TVP, Wolfer DP, Kuhl D. Arg3.1/Arc is essential for the consolidation of synaptic plasticity and memories. Neuron (2006) 52:437-44(2) Waltereit R, Mannhardt S, Nescholta S, Maser-Gluth C, Bartsch D. Selective and protracted effect of nifedipine on fear memory extinction correlates with induced stress response. Learn Mem (2008) 15:348-56(3) Waltereit R, Japs B, Schneider M, de Vries PJ, Bartsch D. Epilepsy and Tsc2 Haploinsufficiency Lead to Autistic-Like Social Deficit Behaviors in Rats. Behav Genet (2011) 41:364-72. Epub 2010 Oct 7(4) Waltereit R, Leimer U, von Bohlen und Halbach O, Panke J, Hölter S, Garrett L, Wittig K, Schneider M, Schmitt C, Calzada-Wack J, Neff F, Becker L, Prehn C, Kutscherjawy S, Endris V, Bacon C, Fuchs H, Gailus-Durner V, Berger S, Schönig K, Adamski J, Klopstock T, Esposito I, Wurst W, Hrabě de Angelis M, Rappold G, Wieland T, Bartsch D. Srgap3-/- mice present a neurodevelopmental disorder with schizophrenia-related intermediate phenotypes. FASEB J (2012) 26:4418-28. Epub 2012 Jul 20(5) Waltereit R, Banaschewski T, Meyer-Lindenberg A, Poustka L. Interaction of neurodevelopmental pathways and synaptic plasticity in mental retardation, autism spectrum disorder and schizophrenia: Implications for psychiatry. World J Biol Psychiatry (2014) 15:507-16. Epub 2013 Sep 30

Links

• to announcement of the organizer

Last modified: Dec 17, 2015, 8:57:30 AM