Neuromesodermal progenitors en route to spinal cord

Datum

26.08.2015

Zeit

10:00 - 11:00

Sprecher

Mina Gouti, PhD, The Francis Crick Institute, London, UK

Serie

CMCB Life Sciences Seminar

Sprache

en

Hauptthema

Biologie

Andere Themen

Biologie, Medizin

Host

Elly Tanaka

Beschreibung

About the research of Mina Gouti: Cells of the spinal cord and somites arise from a shared, dual-fated progenitor population located at the posterior tip of the elongating embryo. I have recently succeeded in generating this neuromesodermal progenitor population (NMPs) in vitro from mouse and human pluripotent stem cells by activating Wnt and Fgf signalling in a timely manner in order to recapitulate in vivo development. Similar to NMPs in vivo, these cells co-express the neural factor Sox2 and the mesodermal factor Brachyury and differentiate into neural and paraxial mesoderm in vitro and in vivo. My future research capitalizes on the use of this system to understand the mechanisms regulating the neural versus mesodermal cell fate decision in the tailbud and the subsequent specification of different types of spinal cord neurons and muscle cells. Efficient generation of these cell types holds great promise for the study, modelling and ultimately treatment of neuromuscular diseases. Publications: Gouti M, Metzis V, Briscoe J. Trends Genet. 2015 Jun;31(6):282-289. doi: 10.1016/j.tig.2015.03.001. Epub 2015 Mar 27. Review. PMID:25823696 Gouti M, Tsakiridis A, Wymeersch FJ, Huang Y, Kleinjung J, Wilson V, Briscoe J. PLoS Biol. 2014 Aug 26;12(8):e1001937. doi: 10.1371/journal.pbio.1001937. PMID:25157815 Bami M, Episkopou V, Gavalas A, Gouti M. PLoS One. 2011;6(5):e20197. doi: 10.1371/journal.pone.0020197. PMID:21637844 Gouti M, Briscoe J, Gavalas A. Stem Cells. 2011 May;29(5):858-70. doi: 10.1002/stem.630. PMID:21433221 Gouti M, Gavalas A. Stem Cells. 2008 Aug;26(8):1985-97. doi: 10.1634/stemcells.2008-0182. PMID:18499896

Links

• to announcement of the organizer

Letztmalig verändert: 26.08.2015, 09:56:22