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UID:DSC-9750
DTSTART;TZID=Europe/Berlin:20151002T110000
SEQUENCE:1443771354
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20151002T120000
URL:https://www.dresden-science-calendar.de/calendar/de/detail/9750
LOCATION:TUD CRTD\, Fetscherstraße 10501307 Dresden
SUMMARY:Grimpe: Regeneration after Spinal Cord Injury: Classical and System
  Biology Approaches
CLASS:PUBLIC
DESCRIPTION:Speaker: Barbara Grimpe\, Heinrich Heine University Düsseldorf
 \nInstitute of Speaker: \nTopics:\nBiologie\, Medizin\n Location:\n  Name:
  TUD CRTD (CRTD\, auditorium left)\n  Street: Fetscherstraße 105\n  City:
  01307 Dresden\n  Phone: +49 (0)351 458 82052\n  Fax: +49 (0)351 458 82059
  \nDescription: About the research of Dr. Grimpe:       The research of my
  laboratory addresses spinal cord injury and the       concomitant failure
  of nerve regeneration. As a possible new       therapeutic we demonstrate
 d the many desirable properties of       deoxyribozymes\, a knock down tec
 hnology able to strongly reduce       the expression of arbitrary proteino
 us inhibitors of axonal       growth. Due to the multitude of involved int
 eracting biomolecules       my laboratory employed more and more sophistic
 ated software tools       in order to cope with complexity\, predict regul
 ation mechanisms       and to identify promising molecular targets. Comput
 er-based       comparative analysis of regenerating and non-regenerating a
 nimals       is forming one new direction of investigations. Through all t
 hat\,       my group became convinced that knowledge representations\,    
    computational modeling and simulation in combination with wet lab      
  experiments will institute a new promising research strategy to       ove
 rcome the barring complexity encountered in such notoriously       hard pr
 oblems like spinal cord injury and regeneration.               Publication
 s:       Lemmon V\, Ferguson A\, Popovich P\, Xu XM\, Snow D\, Igarashi M\
 ,       Beattie C\, Bixby J. Consortium: Abeyruwan S\, Beattie M\, Bethea 
 J\,       Bradke F\, Bresnahan J\, Bunge M\, Callahan A\, David S\, Dunlop
  S\,       Fawcett J\, Fehlings M\, Fischer I\, Giger R\, Goshima Y\, Grim
 pe B\,       Hagg T\, Hall E\, Harrison B\, Harvey A\, He C\, He Z\, Hirat
 a T\, Hoke       A\, Hulsebosch\, Hurtado A\, Jain A et al. (2014) Minimal
  Information       About a Spinal Cord Injury Experiment (MIASCI): a propo
 sed       reporting standard for spinal cord injury experiments\, Journal 
 of       Neurotrauma\, Epub ahead of print      (IF: 4.295) Oudega M\, Cha
 o       OY\, Avison DL\, Bronson RT\, Buchser WJ\, Hurtado A\, Grimpe B (2
 012)       Systemic administration of a deoxyribozyme to xylosyltransferas
 e-1       mRNA promotes recovery after a spinal cord contusion injury\,   
     Experimental Neurology\, 237: 170-179  (IF: 4.699)       Hurtado      
  A\, Podini H\, Oudega M\, Grimpe B (2008) Deoxyribozyme-mediated       kn
 ock down of xylosyltransferase-1 mRNA promotes axon growth in       the ad
 ult rat spinal cord\, Brain 131: 2596-605  (IF: 9.457)                   R
 ies A\, Goldberg JL\, Grimpe B (2007) A novel biological function       fo
 r CD44 in axon growth of retinal ganglion cells identified by a       bioi
 nformatics approach\, Journal of Neurochemistry 103: 1491-1505        (IF:
  4.061)      Grimpe       B\, Silver J (2004) A novel DNA-enzyme reduces g
 lycosaminoglycan       chains in the glial scar and allows microtransplant
 ed DRG axons to       regenerate beyond lesions in the spinal cord\, Journ
 al of       Neuroscience 24: 1393-1397  (IF: 7.27)      Review:       Grim
 pe B (2012) Deoxyribozymes and bioinformatics: Complementary       tools t
 o investigate axon regeneration. Cell Tissue Research\,       349:181-200 
  (IF: 3.114)
DTSTAMP:20261008T134403Z
CREATED:20150804T074633Z
LAST-MODIFIED:20151002T073554Z
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