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UID:DSC-9748
DTSTART;TZID=Europe/Berlin:20150814T130000
SEQUENCE:1439539048
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20150814T140000
URL:https://www.dresden-science-calendar.de/calendar/de/detail/9748
LOCATION:IFW\, Helmholtzstraße 2001069 Dresden
SUMMARY:Beck-Sickinger: Immobilistion and Controlled Activation of Peptide 
 and Proteins
CLASS:PUBLIC
DESCRIPTION:Speaker: Prof.  Annette Beck-Sickinger\nInstitute of Speaker: U
 niversität Leipzig\nTopics:\nMaterialien\, Physik\n Location:\n  Name: IF
 W (D2E.27\, IFW Dreden)\n  Street: Helmholtzstraße 20\n  City: 01069 Dres
 den\n  Phone: \n  Fax: \nDescription: Immobilisation and Controlled Activa
 tion of Peptide and Proteins  Institute of Biochemistry\, Faculty of Biosc
 iences\, Pharmacy and Psychology\, Leipzig University\, Brüderstr. 34\, 0
 4103 Leipzig\, Germany Multifunctionality is gaining more and more importa
 nce in the field of improved biomaterials. Accordingly\, specific and sele
 ctive modification of surfaces is required. Peptides feature a broad chemi
 cal variability and are versatile mediators between inorganic surfaces or 
 polymers and living cells. The fully biodegradable polymer poly(lactic-co-
 glycolic acid) (PLGA) is frequently used for biomedical implants and can b
 e applied as nanoparticles for drug delivery . On the other side inorganic
  surfaces\, e. g. titanium oxide or silicium oxide are frequently used ino
 rganic materials that require specific attachment of cells. We developed s
 everal strategies for immobilization of peptides and proteins on hydrophob
 ic\, hydrophilic and inorganic surfaces using selectively binding peptides
   or bioorthogonal ligation  and click- or click-like reactions. In the ne
 xt step\, we developed linkers for controlled release of therapeutics\, e.
  g. chemokines like interleukin 8  or stromal derived factor 1 alpha (SDF-
 1 alpha) \, which has been shown to promote and initiate migration of prog
 enitor cells. Chemokines were produced recombinantly and chemically modifi
 ed by native chemical ligation strategy . Peptide linkers were obtained by
  solid phase peptide synthesis. By the combination of different strategies
  we could induce cell spreading and cell viability of osteoblasts on inorg
 anic surfaces \, migration of eEPCs towards hydrogel slices  and activatio
 n of chemokines by light . Accordingly\, novel types of biomaterials with 
 significantly improved surfaces have been developed.
DTSTAMP:20260613T070423Z
CREATED:20150803T074745Z
LAST-MODIFIED:20150814T075728Z
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