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UID:DSC-23016
DTSTART;TZID=Europe/Berlin:20260707T093000
SEQUENCE:1783402802
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20260707T103000
URL:https://www.dresden-science-calendar.de/calendar/de/detail/23016
LOCATION:MPI-CBG\, Pfotenhauerstraße 10801307 Dresden
SUMMARY:Plum: Morphogen patterning in dynamic tissues
CLASS:PUBLIC
DESCRIPTION:Speaker: Alexander Plum\nInstitute of Speaker: UCSD\, San Diego
 \, USA\nTopics:\n\n Location:\n  Name: MPI-CBG (MPI-CBG CBG Galleria)\n  S
 treet: Pfotenhauerstraße 108\n  City: 01307 Dresden\n  Phone: +49 351 210
 -0\n  Fax: +49 351 210-2000\nDescription: Embryogenesis integrates morphog
 enesis—coordinated cell movements—with cell differentiation. Morphogen
 esis and patterning often unfold simultaneously in early embryos. Yet how 
 cell movements affect morphogen transport and cells' exposure over time re
 mains unclear\, as most pattern formation models assume static tissues. He
 re we develop a theoretical framework for morphogen patterning in dynamic 
 tissues\, recasting advection-reaction-diffusion equations in the cells' m
 oving reference frames. This framework (i) elucidates how morphogenesis ca
 n mediate morphogen transport and compartmentalization: cell-cell diffusiv
 e transport is enhanced at multicellular flow attractors\, while repellers
  act as barriers\, affecting cell fate induction and bifurcations. (ii) It
  formalizes cell-cell signaling ranges in dynamic tissues\, deconfounding 
 morphogenetic movements to identify which cells could communicate via morp
 hogens. (iii) It provides two new nondimensional numbers to assess when an
 d where morphogenesis affects morphogen transport. We demonstrate this fra
 mework by analyzing classical patterning models with common morphogenetic 
 motifs as well as experimental tissue flows. Our work rationalizes dynamic
  tissue patterning in development\, constraining candidate patterning mech
 anisms and parameters using accessible cell motion data.
DTSTAMP:20260826T003354Z
CREATED:20260702T053820Z
LAST-MODIFIED:20260707T054002Z
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