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UID:DSC-22865
DTSTART;TZID=Europe/Berlin:20260508T100000
SEQUENCE:1778218568
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20260508T110000
URL:https://www.dresden-science-calendar.de/calendar/de/detail/22865
LOCATION:MPI-CBG\, Pfotenhauerstraße 10801307 Dresden
SUMMARY:Rossi: One receptor\, two functions: how a GPCR regulates sleep ons
 et and duration in C. elegans
CLASS:PUBLIC
DESCRIPTION:Speaker: Lorenzo Rossi\nInstitute of Speaker: Bringmann Lab\, B
 IOTEC\, TU Dresden\nTopics:\n\n Location:\n  Name: MPI-CBG (MPI-CBG CBG Ga
 lleria II (VC))\n  Street: Pfotenhauerstraße 108\n  City: 01307 Dresden\n
   Phone: +49 351 210-0\n  Fax: +49 351 210-2000\nDescription: Sleep is an 
 essential state that fulfills higher brain functions as well as basic vita
 l processes. Too little or excessive sleep impairs sleep functions\, drivi
 ng the evolutionary need for precise neural mechanisms that regulate sleep
  duration. Sleep-active neurons release neurotransmitters and neuropeptide
 s upon depolarization to determine when an organism falls asleep. In C. el
 egans\, the depolarization of the single sleep-active neuron RIS determine
 s sleep via the release of the FLP-11 neuropeptide. Yet\, how RIS and FLP-
 11 control sleep remains unclear. In this talk\, I will present how RIS an
 d FLP-11 control sleep through the Gi/o-protein coupled receptor DMSR-1. I
  will show how\, using cell-specific knockdowns\, we demonstrate that dmsr
 -1 induces sleep by acting in cholinergic neurons\, while the receptor med
 iates negative feedback control of RIS that limits sleep duration. Thus\, 
 DMSR-1 controls both the initiation and limitation of sleep\, effectively 
 coupling sleep induction with a sleep-stop signal. Neuropeptide-GPCR signa
 ling might underlie similar dual mechanisms of sleep control in other spec
 ies\, and self-inhibition of sleep-active neurons might represent a conser
 ved mechanism for limiting the duration of sleep.
DTSTAMP:20260618T181704Z
CREATED:20260430T053529Z
LAST-MODIFIED:20260508T053608Z
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