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BEGIN:VEVENT
UID:DSC-22734
DTSTART;TZID=Europe/Berlin:20260521T110000
SEQUENCE:1778990877
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20260521T120000
URL:https://www.dresden-science-calendar.de/calendar/de/detail/22734
LOCATION:MPI-CBG\, Pfotenhauerstraße 10801307 Dresden
SUMMARY:Tabler: Constructing connective tissues across scales
CLASS:PUBLIC
DESCRIPTION:Speaker: Jacqueline Tabler\nInstitute of Speaker: Max Planck In
 stitute of Cell Biology and Genetics\nTopics:\n\n Location:\n  Name: MPI-C
 BG (MPI-CBG CBG Large Auditorium)\n  Street: Pfotenhauerstraße 108\n  Cit
 y: 01307 Dresden\n  Phone: +49 351 210-0\n  Fax: +49 351 210-2000\nDescrip
 tion: Mesenchymal tissues construct the physical architecture of the devel
 oping skull through dynamic interactions between cells and extracellular m
 atrix. Our work investigates how extracellular matrix organization and mec
 hanics regulate mesenchymal cell fate decisions during cranial morphogenes
 is\, and how disruption of these processes may contribute to connective ti
 ssue pathology. Using embryonic perturbation models\, quantitative tissue 
 imaging\, and single-cell approaches\, we show that altered matrix crossli
 nking changes the tempo and spatial organization of connective tissue spec
 ialization within the developing skull cap. These findings suggest that co
 nnective tissue disease may emerge not only from defects in structural mol
 ecules themselves\, but from altered developmental states that reshape how
  cells interpret and build their extracellular environments across scales.
DTSTAMP:20260518T004742Z
CREATED:20260305T063928Z
LAST-MODIFIED:20260517T040757Z
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