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UID:DSC-22701
DTSTART;TZID=Europe/Berlin:20260309T140000
SEQUENCE:1773038377
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20260309T150000
URL:https://www.dresden-science-calendar.de/calendar/de/detail/22701
LOCATION:MPI-CBG\, Pfotenhauerstraße 10801307 Dresden
SUMMARY:Lissek: High-Throughput Single-Molecule Analysis of DNA-Protein Int
 eractions Using DNA Curtains
CLASS:PUBLIC
DESCRIPTION:Speaker: Emanuel N. Lissek\nInstitute of Speaker: 1NA Technolog
 ies B.V.\nTopics:\n\n Location:\n  Name: MPI-CBG (MPI-CBG CBG Galleria)\n 
  Street: Pfotenhauerstraße 108\n  City: 01307 Dresden\n  Phone: +49 351 2
 10-0\n  Fax: +49 351 210-2000\nDescription: DNA curtains are a high-throug
 hput single-molecule assay that enables simultaneous visualization of thou
 sands of DNA-protein interactions\, revealing statistically relevant singl
 e-molecule level insights. DNA molecules are aligned on nanofabricated bar
 riers within a microfluidics flow cell\, allowing real-time observation of
  dynamic processes such as DNA replication\, and repair\, using TIRF micro
 scopy and/or spinning disk confocal microscopy.  1NA's DNA curtains flow c
 ell addresses key barriers of implementation by applying semiconductor man
 ufacturing practices to the nanofabrication of the barriers. Flow cell des
 ign minimizes dead volume and reagent use\, while protocols have been opti
 mized for rapid setup. This approach preserves the resolution of single-mo
 lecule methods while overcoming throughput limitations. It is particularly
  well-suited for in vitro studies of DNA-binding proteins or the mechanist
 ic characterization of small-molecule modulators. Applications include qua
 ntifying DNA-protein kinetics\, mapping interaction heterogeneity\, or scr
 eening small molecule interactions.
DTSTAMP:20260416T070027Z
CREATED:20260225T063653Z
LAST-MODIFIED:20260309T063937Z
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