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UID:DSC-22065
DTSTART;TZID=Europe/Berlin:20250728T163000
SEQUENCE:1753680912
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20250728T173000
URL:https://www.dresden-science-calendar.de/calendar/de/detail/22065
LOCATION:MPI-PKS\, Nöthnitzer Straße 3801187 Dresden
SUMMARY:Kardar: Specificity and tolerance of the immune T cell repertoire
CLASS:PUBLIC
DESCRIPTION:Speaker: Prof. Mehran Kardar\nInstitute of Speaker: MIT\nTopics
 :\nPhysik\n Location:\n  Name: MPI-PKS ()\n  Street: Nöthnitzer Straße 3
 8\n  City: 01187 Dresden\n  Phone: + 49 (0)351 871 0\n  Fax: \nDescription
 : The adaptive immune system protects the body from an ever-changing lands
 cape of foreign pathogens. The two arms of the adaptive immune system\, T 
 cells and B cells\, mount specific responses to pathogens by utilizing the
  diversity of their receptors\, generated through hypermutation. T cells r
 ecognize and clear infected hosts when their highly variable receptors bin
 d sufficiently strongly to antigen-derived peptides displayed on a cell su
 rface. To avoid auto-immune responses\, randomly generated receptors that 
 bind strongly to self-peptides are eliminated in the “central\" process 
 of thymic selection\, ensuring a mostly self-tolerant repertoire of mature
  T cells. “Peripheral” tolerance\, including a quorum mechanism furthe
 r protects against self-targeting T cells that escape thymic selection. We
  discuss how these mechanisms can still fail during persistent infections.
DTSTAMP:20260510T044221Z
CREATED:20250612T053542Z
LAST-MODIFIED:20250728T053512Z
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