ATP regulates tau-microtubule interaction

Datum

27.11.2025

Zeit

11:00 - 12:00

Sprecher

Zdeněk Lánský

Zugehörigkeit

BIOCEV Prague, Czechia

Serie

MPI-CBG Thursday Seminar

Sprache

en

Hauptthema

Biologie

Host

Pavel Tomancak

Beschreibung

Neuronal microtubule-associated protein tau can protect the microtubule surface, maintaining microtubule stability. In neurodegenerative diseases termed tauopathies, tau forms cyto-toxic aggregates presumably as a consequence of tau delocalization from microtubules, accompanied by an increase in cytoplasm-localized tau and microtubule destabilization. The underlying mechanisms, however, remain unclear. Here, we show that decline of adenosine triphosphate (ATP), related to aging and neurodegeneration, leads to tau delocalization from microtubules and microtubule disintegration. Combining reconstitution experiments with molecular modeling, we show that ATP stabilizes tau molecules on the microtubule surface through electrostatic interactions. We propose that pathological decline of ATP can destabilize microtubule-tau interactions and lead to an increase of cytoplasmic tau, providing a plausible functional link between ATP homeostasis and tauopathies.

Letztmalig verändert: 27.11.2025, 07:39:00