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CMCB Life Sciences Seminar: Prof. Anne-Florence Bitbol, EPFL, Instiute of Bioengineering, Switzerland

Datum
05.06.2025
Zeit
13:00 - 14:00
Serie
CMCB Life Sciences Seminar
Sprache
en
Hauptthema
Willkommen
Andere Themen
Biologie, Willkommen
Beschreibung

Host: James Sáenz

Title: "Predicting interaction partners and generating new protein sequences using protein language models"

Abstract: Protein language models trained on multiple sequence alignments of homologous proteins successfully capture coevolution between amino acids in structural contact: this is one of the ingredients of the success of AlphaFold. We have used such models, especially MSA Transformer, to generate new protein sequences from given protein families, and to predict which proteins interact among the members of two protein families. Despite their successes, a drawback of models based on multiple sequence alignments is that sequence alignment can be imperfect. Thus, we are developing ProtMamba, a homology-aware but alignment-free protein language model. ProtMamba starts from concatenated homologous sequences, is based on the Mamba state-space model architecture, has promising generative properties, and is able to predict fitness.

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Letztmalig verändert: 05.06.2025, 07:38:55

Veranstaltungsort

Center for Regenerative Therapies DresdenFetscherstraße10501307Dresden
Telefon
+49 (0)351 458 82052
Fax
+49 (0)351 458 82059
E-Mail
TUD CRTD
Homepage
https://tu-dresden.de/cmcb/crtd

Veranstalter

Center for Molecular and Cellular Bioengineering (CMCB)01062Dresden
Telefon
+49 351 463-40359
Fax
+49 351 463-40322
E-Mail
TUD CMCB
Homepage
https://tu-dresden.de/cmcb
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