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UID:DSC-21388
DTSTART;TZID=Europe/Berlin:20241107T130000
SEQUENCE:1730967295
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URL:https://www.dresden-science-calendar.de/calendar/de/detail/21388
LOCATION:TUD Materials Science - HAL\, Hallwachsstraße 301069 Dresden
SUMMARY:Korecká: Electrochemical Immunoassay-based Sensors Towards Point-O
 f-Care Diagnostics: Recent Progress and Challenges in Multiple Biomarkers 
 Detection
CLASS:PUBLIC
DESCRIPTION:Speaker: Zuzana Bílková and Lucie Korecká\nInstitute of Spea
 ker: Department of Biological and Biochemical Sciences\, Faculty of Chemic
 al-Technology\, Czech Republic\nTopics:\nPhysik\n Location:\n  Name: TUD M
 aterials Science - HAL (HAL Bürogebäude - 115)\n  Street: Hallwachsstra
 ße 3\n  City: 01069 Dresden\n  Phone: \n  Fax: \nDescription: Specific bi
 omarkers detected in body fluids and tissues are crucial elements for dise
 ase diagnosis\, prediction of its progression\, and evaluation of personal
 ised treatment effectiveness. Although the detection of a single specific 
 biomarker is sufficient\, the simultaneous detection of multiple disease-a
 ssociated biomarkers (cancer biomarkers\, inflammatory proteins\, etc.) si
 gnificantly improves the diagnostic power of biomarkers in terms of specif
 icity and sensitivity from the Receiver operating characteristic curve (RO
 C).&amp\;#13\; Electrochemical biosensors meet the criteria of Point-of-Ca
 re (POCT) devices and represent the alternative to commonly used instrumen
 tally and time-consuming laborious diagnostic methods (ELISA\, immunohisto
 chemistry\, PCR). Among electrochemical biosensors\, immunosensors\, based
  on the principle of highly specific affinity interactions between antigen
 s and two corresponding antibodies identical to the ELISA method\, are of 
 interest in clinical diagnosis. Increasingly\, the common enzyme-based imm
 unosensors are being replaced by nanomaterials-based sensors to overcome t
 he shortcomings of enzymes. From electroactive nanoparticles\, gold nanopa
 rticles (AuNPs)\, silver nanoparticles (AgNPs)\, quantum dots (QDs)\, carb
 on nanotubes (CNTs)\, graphene\, and carbon quantum dots (CQDs) are the mo
 st commonly used. Moreover\, these nanomaterials enable the simultaneous d
 etection of multiple biomarkers since they provide separate\, non-interfer
 ing and mutually unaffected electrochemical signals.&amp\;#13\; The talk w
 ill be focused on the development of electrochemical magneto-immunoassay-b
 ased sensors for simultaneous stripping voltammetric detection of ovarian 
 cancer biomarkers\, namely proteins HE4\, CA125\, AFP\, and pro-inflammato
 ry biomarkers PTX3 and CALR\, as potential predictive markers of preterm l
 abour.
DTSTAMP:20260704T005032Z
CREATED:20241017T053908Z
LAST-MODIFIED:20241107T081455Z
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