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BEGIN:VEVENT
UID:DSC-21328
DTSTART;TZID=Europe/Berlin:20241205T110000
SEQUENCE:1733380573
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20241205T120000
URL:https://www.dresden-science-calendar.de/calendar/de/detail/21328
LOCATION:MPI-CBG\, Pfotenhauerstraße 10801307 Dresden
SUMMARY:Zechner: Stochastic processes in cells in tissues
CLASS:PUBLIC
DESCRIPTION:Speaker: Christoph Zechner\nInstitute of Speaker: MPI-CBG\nTopi
 cs:\n\n Location:\n  Name: MPI-CBG (MPI-CBG: Auditorium Large)\n  Street: 
 Pfotenhauerstraße 108\n  City: 01307 Dresden\n  Phone: +49 351 210-0\n  F
 ax: +49 351 210-2000\nDescription: Stochastic phenomena play a fundamental
  role in many biological systems\, ranging from gene regulation to cell-fa
 te determination. Understanding such phenomena raises new theoretical chal
 lenges at the interface between stochastic processes\, statistical physics
  and computation. In this talk I will present some of our group’s work i
 n this direction. In the first part of the talk\, I will show how cells ca
 n use phase coexistence to control and suppress protein concentration fluc
 tuations. Using a non-equilibrium model that links active protein synthesi
 s and turnover to the physics of phase separation\, I will show that conce
 ntration fluctuations can be strongly reduced in the presence of phase sep
 arated compartments. I will present experimental single-cell data in synth
 etic and endogenous compartments\, which support this prediction. In the s
 econd part of my talk\, I will focus on inverse problems and how stochasti
 c processes can be robustly inferred from limited experimental data. As an
  example\, I will present a statistical method to quantify CTCF/cohesion-m
 ediated chromatin looping dynamics from two-point live-imaging measurement
 s. The method combines a simple polymer model with a Bayesian filtering ap
 proach to infer loop lifetimes and frequencies. When applied to experiment
 al data\, this method revealed that chromatin loops are surprisingly rare 
 and short-lived. I will conclude my talk by outlining several important ch
 allenges for the future.
DTSTAMP:20260507T050458Z
CREATED:20240925T144904Z
LAST-MODIFIED:20241205T063613Z
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