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UID:DSC-21220
DTSTART;TZID=Europe/Berlin:20240809T110000
SEQUENCE:1723268107
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20240809T120000
URL:https://www.dresden-science-calendar.de/calendar/de/detail/21220
LOCATION:MPI-CBG\, Pfotenhauerstraße 10801307 Dresden
SUMMARY:Siryaporn: Bacterial collectives and antibacterial synergy
CLASS:PUBLIC
DESCRIPTION:Speaker: Albert Siryaporn\nInstitute of Speaker: University of 
 California Irvine\nTopics:\n\n Location:\n  Name: MPI-CBG (CSBD SR Ground 
 Floor)\n  Street: Pfotenhauerstraße 108\n  City: 01307 Dresden\n  Phone: 
 +49 351 210-0\n  Fax: +49 351 210-2000\nDescription: The perpetuation of b
 acteria in multi-species communities is affected by how species interact. 
 In particular\, bacterial populations may employ mechanisms that enable mu
 ltiple species to coexist. We investigate the interactions between two opp
 ortunistic pathogens\, P. aeruginosa and S. aureus\, on a porous surface. 
 Using an imaging method that we recently developed\, Imaging using Reflect
 ed Illuminated Structures (IRIS)\, we find that both species coexist and p
 roliferate but remain physically segregated due the interactions between s
 urfactant produced by P. aeruginosa and amyloid fibrils produced by S. aur
 eus. This interaction gives rise to dense single-species populations that 
 are spatially separated. Our findings suggest that surfactant interactions
  can have a critical role in determining how bacterial species interact an
 d whether they can coexist. To complement our understanding of bacterial c
 olonization\, we have investigated mechanisms that mammalian hosts employ 
 to eradicate bacteria. We have identified that histones\, which organize D
 NA in mammalian cells\, synergize with pore-forming antimicrobial peptides
  to kill bacteria. We find that the entry of histones into bacteria re-org
 anizes their chromosomes and inhibits transcription\, leading to bacterial
  death. Our findings suggest a novel antimicrobial mechanism that is achie
 ved through differential targeting by histones and antimicrobial peptides.
  This synergistic mechanism can potentially be exploited to establish a ne
 w class of potent antimicrobials.
DTSTAMP:20260818T105355Z
CREATED:20240807T053810Z
LAST-MODIFIED:20240810T053507Z
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