Electronic Nano-biosensors Based on Graphene Transistors

Datum

04.07.2024

Zeit

13:00 - 15:00

Sprecher

Zhaoli Gao

Zugehörigkeit

Chinese University of Hong Kong

Serie

TUD nanoSeminar

Sprache

en

Hauptthema

Physik

Andere Themen

Physik

Host

Arezoo Dianat

Beschreibung

Probing biosystems with two-dimensional (2D) materials provides tremendous opportunities for highly sensitive detection of physiological properties at the molecular level, which can pave the way toward early-stage disease diagnosis and improved healthcare outcomes. In this talk, I will introduce the process we have developed for scalable fabrication of 2D-biosensor arrays for multiplexed detection of disease biomarkers, where a graphene field effect transistor (GFET) is utilized for signal transduction, and a biomolecular layer, e.g., protein, nuclide acid, serves as the biological recognition element. Further, integrating the hybridization chain reaction (HCR) process with GFET readout leads to oligonucleotide detection with sensitivity at the aM level. Looking to the future, I will discuss the synthesis of crystalline multilayer graphene and transition metal dichalcogenide materials with band gaps, providing a pathway toward next-generation biosensors with even greater sensitivity. Finally, I will discuss the ongoing development of a universal sensing platform based on aptamer-GFET biosensors that is potentially useful for wearable electronics for detecting health and performance biomarkers in sweat. Probing biosystems with two-dimensional (2D) materials provides tremendous opportunities for highly sensitive detection of physiological properties at the molecular level, which can pave the way toward early-stage disease diagnosis and improved healthcare outcomes. In this talk, I will introduce the process we have developed for scalable fabrication of 2D-biosensor arrays for multiplexed detection of disease biomarkers, where a graphene field effect transistor (GFET) is utilized for signal transduction, and a biomolecular layer, e.g., protein, nuclide acid, serves as the biological recognition element. Further, integrating the hybridization chain reaction (HCR) process with GFET readout leads to oligonucleotide detection with sensitivity at the aM level. Looking to the future, I will discuss the synthesis of crystalline multilayer graphene and transition metal dichalcogenide materials with band gaps, providing a pathway toward next-generation biosensors with even greater sensitivity. Finally, I will discuss the ongoing development of a universal sensing platform based on aptamer-GFET biosensors that is potentially useful for wearable electronics for detecting health and performance biomarkers in sweat.

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Letztmalig verändert: 04.07.2024, 07:40:05