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UID:DSC-20805
DTSTART;TZID=Europe/Berlin:20240620T110000
SEQUENCE:1718948290
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20240620T120000
URL:https://www.dresden-science-calendar.de/calendar/de/detail/20805
LOCATION:MPI-CBG\, Pfotenhauerstraße 10801307 Dresden
SUMMARY:Poolman: Synthetic Non-Equilibrium Vesicle Systems for Physicochemi
 cal Homeostasis and Membrane Transport
CLASS:PUBLIC
DESCRIPTION:Speaker: Bert Poolman\nInstitute of Speaker: University of Gron
 ingen\nTopics:\n\n Location:\n  Name: MPI-CBG (MPI-CBG Auditorium (big hal
 f))\n  Street: Pfotenhauerstraße 108\n  City: 01307 Dresden\n  Phone: +49
  351 210-0\n  Fax: +49 351 210-2000\nDescription: One of the grand challen
 ges in synthetic biology is the construction of selectively open molecular
  systems integrated into cell-like containers with control of solute fluxe
 s and a constant supply of energy to fuel ATP-requiring processes. Such sy
 stems should enable long-term metabolic energy conservation and physicoche
 mical homeostasis and a better understanding of how living cells perform t
 hese tasks.   In living cells metabolic reaction networks orchestrate the 
 supply\, regeneration\, and removal of energy. These energy modules are re
 sponsible for the almost flawless exertion of all cellular functions\, and
  thus\, sustaining life. In contrast\, the prolonged performance of man-ma
 de non-equilibrium systems is often limited by the availability of fuel mo
 lecules or the accumulation of waste products due to a lack of control mec
 hanisms. Here\, we present synthetic vesicle systems that allow for the co
 mpartmentalization of ATP-driven non-equilibrium processes and the recycli
 ng of ATP by means of the continuous import of ATP into the lumen and conc
 omitant export of ADP from the lumen. The ATP and proton motive force gene
 rating networks we developed for studying metabolic processes in vesicles 
 perform at least an order of magnitude better than other systems described
  so far. They enable control of the volume\, osmotic pressure\, ionic stre
 ngth and pH of the vesicles\, and allow for cross-feeding of ATP between d
 ifferent populations of vesicles\, and the synthesis of lipid precursors a
 nd membrane growth.
DTSTAMP:20260418T010511Z
CREATED:20240418T053952Z
LAST-MODIFIED:20240621T053810Z
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