Host: James Sáenz (B CUBE)
Title: \"How are membranes and their proteins matched?\"
Abst ract: Membranes and their lipidomes vary substantially — across the tree of life\, among the different cells of a metazoan\, and between the different membranes within a single eukaryotic cell. The lipid composi tion of a membrane and how those lipids are distributed determines the str uctural and physico-chemical properties of the membrane\, which are adapte d to support particular functions. For example\, the membrane of the endop lasmic reticulum is simple\, loosely packed\, and deformable\, facilitatin g folding and insertion of membrane proteins during synthesis\, while the plasma membrane features a complex mixture of lipids and cholesterol\, dis tributed asymmetrically between the two leaflets. In this talk\, I will di scuss our recent efforts to determine the asymmetric distribution of lipid s in mammalian plasma membranes\, and how this asymmetry (and its loss) mi ght couple to signaling in the GPCR family. I will finish by discussing our recent efforts to address this question more generally\, by training g raph neural network representations of membrane proteins. By leveraging pr oteome-wide structure databases\, we hope to uncover rules for membrane pr oteins across the tree of life.
DTSTAMP:20260508T174945Z CREATED:20240319T063852Z LAST-MODIFIED:20240926T053634Z END:VEVENT END:VCALENDAR