Structure, function, and evolutionary conservation in ATP synthase

Datum

31.01.2023

Zeit

15:00 - 16:00

Sprecher

Pablo Sartori

Zugehörigkeit

IGC, Portugal

Sprache

en

Hauptthema

Biologie

Host

Carl Modes

Beschreibung

One of the tenets of molecular biology is that dynamical transitions between three dimensional structures largely determine the function of proteins. Therefore, it seems only natural that evolutionary analysis of proteins, presently based on their primary sequence, needs to shift its focus towardsprotein function, as assessed by corresponding structural transitions. We will show how to adapt the formalism of finite strain analysis, developed in condensed matter physics and engineering, and apply it to structural transitions of proteins. As a case study, we will focus on the ATP synthase, for which our Protein Strain Analysis (PSA) provides a strain distribution on the protein structure associated with functional transitions. By analyzing the strain patterns for ATP synthases across different species, we show that they are evolutionarily conserved for the same functional transition. This observed strain conservation across evolutionary distant species indicates that this quantity should be essential in future structure-based evolutionary studies of protein function.

Letztmalig verändert: 01.02.2023, 07:36:47