Bi

Cellular responses to tissue mechanical stress

Datum
30.06.2022
Zeit
11:00 - 12:00
Sprecher
Guillaume Charras
Zugehörigkeit
London Centre for Nanotechnology, University College London, UK
Serie
MPI-CBG Thursday Seminar
Sprache
en
Hauptthema
Biologie
Host
Byung Ho Lee on behalf of the postdocs
Beschreibung
Throughout embryogenesis and in adult physiology, living tissues are continuously exposed to mechanical stress. In development, tissue stress has been shown to act as a signal that orients cell divisions and guides tissue growth. While mitotic spindles have been shown to reorient in response to external mechanical stresses, the subcellular cues that mediate spindle reorientation remain unclear. I will present experiments investigating how mitotic spindles respond to inhomogeneous tension along the surface of the mitotic cell. Rupture is a constant risk for many tissues and it can arise due to excessive stresses or because of tissue weakening by genetic abnormalities or pathologies. Tissue fracture is a multi-scale process involving the unzipping of intercellular adhesions at the molecular scale in response to stresses arising at the tissue-scale or cellular-scale transmitted to adhesion complexes through the cytoskeleton. I will present work characterising tissue fracture and highlight a crucial role for intermediate filaments in protecting tissues against rupture.

Letztmalig verändert: 30.06.2022, 00:08:47

Veranstaltungsort

Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG Auditorium)Pfotenhauerstraße10801307Dresden
Telefon
+49 351 210-0
Fax
+49 351 210-2000
E-Mail
MPI-CBG
Homepage
http://www.mpi-cbg.de

Veranstalter

Max Planck Institute of Molecular Cell Biology and GeneticsPfotenhauerstraße10801307Dresden
Telefon
+49 351 210-0
Fax
+49 351 210-2000
E-Mail
MPI-CBG
Homepage
http://www.mpi-cbg.de
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