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UID:DSC-17741
DTSTART;TZID=Europe/Berlin:20210617T110000
SEQUENCE:1623967722
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20210617T120000
URL:https://www.dresden-science-calendar.de/calendar/de/detail/17741
LOCATION:MPI-CBG\, Pfotenhauerstraße 10801307 Dresden
SUMMARY:Mateus: Growth and Scaling in Zebrafish Fins   
CLASS:PUBLIC
DESCRIPTION:Speaker: Rita Mateus\nInstitute of Speaker: MPI-CBG Dresden\nTo
 pics:\n\n Location:\n  Name: MPI-CBG (Zoom online)\n  Street: Pfotenhauers
 traße 108\n  City: 01307 Dresden\n  Phone: +49 351 210-0\n  Fax: +49 351 
 210-2000\nDescription: Secreted growth factors can act as morphogens that 
 form spatial concentration gradients in developing organs\, thereby contro
 lling growth and patterning. For some morphogens\, adaptation of the gradi
 ents to tissue size allows morphological patterns to remain proportioned a
 s the organs grow. In the zebrafish pectoral fin\, we found that BMP signa
 lling forms a two&amp\;#8209\;dimensional gradient. The length of the grad
 ient scales with tissue length and its amplitude increases with fin size a
 ccording to a power-law. Gradient scaling and amplitude power&amp\;#8209\;
 laws are signatures of growth control by time derivatives of morphogenetic
  signalling: cell division correlates with the fold change over time of th
 e cellular signalling levels. We show that Smoc1 regulates BMP gradient sc
 aling and growth in the fin. Smoc1 scales the gradient by means of a feedb
 ack loop: Smoc1 is a BMP agonist and BMP signalling represses Smoc1 expres
 sion. Our work uncovers a novel layer of morphogen regulation during verte
 brate appendage development.
DTSTAMP:20260628T204130Z
CREATED:20210217T230528Z
LAST-MODIFIED:20210617T220842Z
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