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CMCB Life Sciences Seminar: Active deformation of the cell membrane through actin assembly, and how we may infer nucleus deformation

Datum
28.05.2020
Zeit
13:00 - 14:00
Serie
CMCB Life Sciences Seminar
Sprache
en
Hauptthema
Willkommen
Andere Themen
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Beschreibung

Link (https://tu-dresden.zoom.us/j/93427058190?pwd=dm1JRGVDeGczc1k1Y2hlOGx4eGtMQT09)to the conference -  Zoom Meeting ID: 934 2705 8190, Password: 175528



Abstract:



We conceive stripped-down experimental systems that reproduce cellular behaviours in simplified conditions: cytoskeleton dynamics are reproduced on liposome membranes. By changing experimentally membrane tension and the structural details of the cytoskeleton architecture, we draw a phase diagram where inward or outward deformations are favoured. We observe buckling and wrinkling under osmotic deflation, thereby confirming network elastic properties. Our results illustrate the generic mechanism of buckling and wrinkling found in various systems spanning from pollen grains to the development of the gut or the brain.



Inspired by actin forces exerted on membranes and organelles, we address now how the nucleus, which is the most rigid cell organelle, is deformed by the actin cytoskeleton during cell translocation.



5 most important publications:



C. Simon, V. Caorsi, C. Campillo, C. Sykes, "Interplay between membrane tension and the actin cytoskeleton determines shape changes",Physical Biology, 5(6):065004, doi: 10.1088/1478-3975/aad1ab. (2018)



A. Allard, M. Bouzid, T. Betz, C. Simon, M. Abou-Ghali, J. Lemière, F. Valentino, J. Manzi, F. Brochard-Wyart, K. Guevorkian, J. Plastino, M. Lenz, C. Campillo*, C. Sykes*, "Actin modulates shape and mechanics of tubular membranes” bioRxiv 712505; doi: https://doi.org/10.1101/712505 (https://doi.org/10.1101/712505), and, Science advances in press



C. Simon, R. Kusters, V. Caorsi, A. Allard, M. Abou-Ghali, J. Manzi, A. Di Cicco, D. Lévy, M. Lenz, J.-F. Joanny, C. Campillo, J. Plastino, P. Sens, C. Sykes " Actin dynamics drive cell-like membrane deformation " Nature Physics, https://doi.org/10.1038/s41567-019-0464-1 (https://doi.org/10.1038/s41567-019-0464-1) (2019)



R. Kusters, C. Simon, R. Lopes Dos Santos, V. Caorsi, Sangsong Wu, J.-F. Joanny, P. Sens, C. Sykes, “Actin shells control buckling and wrinkling of biomembranes” Soft Matter, 15, 9647 – 9653 doi: 10.1039/c9sm01902b (2019)



P.M. Davidson, A. Battistella, T. Déjardin, T. Betz, J. Plastino, N. Borghi, B. Cadot, C. Sykes “Actin accumulates nesprin-2 at the front of the nucleus during confined cell migration” bioRxiv 713982; doi: https://doi.org/10.1101/713982 (https://doi.org/10.1101/713982), EMBO Reports, in press

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Letztmalig verändert: 27.05.2020, 00:05:33

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Center for Regenerative Therapies DresdenFetscherstraße10501307Dresden
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+49 (0)351 458 82064
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+49 (0)351 458 82059
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TUD CRTD
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Center for Molecular and Cellular Bioengineering (CMCB)01062Dresden
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+49 351 463-40359
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+49 351 463-40322
E-Mail
TUD CMCB
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https://tu-dresden.de/cmcb
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