Bi

De Humani corporis fabrica:replaying Vesalius through brain organoids at single cell omic resolution

Datum
26.11.2020
Zeit
11:00 - 12:00
Sprecher
Giuseppe Testa
Zugehörigkeit
University of Milan & Human Technopole, Milan, Italy
Serie
MPI-CBG Thursday Seminar
Sprache
en
Hauptthema
Biologie
Host
Wieland Huttner/Nereo Kalebic
Beschreibung
In vitro models of human development are transforming biomedicine by making the developmental potential of individual genomes experimentally tractable. For developmental disorders as well as for late-onset disorders with an early developmental seeding, this patient-specific re-enactment of development promises to bridge altered developmental trajectories to clinical phenotypes at unprecedented resolution, especially through the pairing of single cell multi-omics with digital phenotyping. With the increasing scalability of in vitro organoidogenesis, the prospect is thus within reach for a systematic exploration, including a mechanistic dissection, of how genetic variation shapes the human developmental space, an intellectual pursuit with far reaching implications that requires scientific as well as ethical benchmarking.
Here I lay out the principles for such benchmarking, starting from our most recent modelling of a particularly informative set of neurodevelopmental disorders caused by point mutations or dosage imbalances in chromatin regulators that operate in inter-related pathways. I present our single-cell level deconvolution, in brain organoids, of dosage-dependent alterations in developmental pathways along with a transcriptome-based benchmarking that allows us to empirically assess how far different paradigms of brain organoidogenesis recapitulate human brain development and match specific experimental needs. This benchmarking pipeline is then applied to the quest for convergent dysregulation across neurodevelopmental disorders and to multiplexed designs, experimental and computational alike, in order to advance the field towards population-level scalability

Letztmalig verändert: 27.11.2020, 00:09:13

Veranstaltungsort

Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG Auditorium (big half))Pfotenhauerstraße10801307Dresden
Telefon
+49 351 210-0
Fax
+49 351 210-2000
E-Mail
MPI-CBG
Homepage
http://www.mpi-cbg.de

Veranstalter

Max Planck Institute of Molecular Cell Biology and GeneticsPfotenhauerstraße10801307Dresden
Telefon
+49 351 210-0
Fax
+49 351 210-2000
E-Mail
MPI-CBG
Homepage
http://www.mpi-cbg.de
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