BiMe

Aged Related Degenerative Disease and Genome Instability

Datum
25.11.2019
Zeit
17:00 - 18:00
Sprecher
Prof. Fred H. Gage
Zugehörigkeit
The Salk Institute for Biological Studies, La Jolla, California
Sprache
en
Hauptthema
Biologie
Andere Themen
Biologie, Medizin
Host
Prof. Gerd Kempermann (DZNE/CRTD)
Beschreibung
Abstract:Humans are exceptionally long-lived in comparison to other primates, with a projected maximum lifespan of ~115 years. This extreme longevity presents unique challenges to many of the post-mitotic cells that compose our bodies and makes us highly susceptible to age-associated diseases (AADs) such as cancer, diabetes, and various neurodegenerative diseases. In the first part of this presentation I will address the key features of aging that appear to drive neurodegeneration, compare the iPSC and direct conversion approaches for next-generation human cellular modeling, and discuss the extent to which iNs reflect aged neurons.
Human neurons contain high levels of somatic genomic variations that might derive from DNA double-strand break (DSB) intermediates. For the second part of my presentation, we applied high throughput genome-wide translocation sequencing to study replication stress-induced DSB hotspots, and identified replication-associated genomic fragile regions overlapping genes in neural progenitor cells (NPCs) derived from human pluripotent stem cells. Our results demonstrate that replication-associated genome instability may lead to neurological dysfunction by disrupting long neural genes linked to neurodevelopmental diseases.
Links

Letztmalig verändert: 16.11.2019, 00:08:37

Veranstaltungsort

DFG Center for Regenerative Therapies Dresden (CRTD, ground floor, auditorium)Fetscherstraße10501307Dresden
Telefon
+49 (0)351 458 82064
Fax
+49 (0)351 458 82059
E-Mail
CRTD
Homepage
http://www.crt-dresden.de

Veranstalter

DFG Center for Regenerative Therapies DresdenFetscherstraße 10501307Dresden
Telefon
+49 (0)351 458 82064
Fax
+49 (0)351 458 82059
E-Mail
CRTD
Homepage
http://www.crt-dresden.de
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