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UID:DSC-16593
DTSTART;TZID=Europe/Berlin:20191024T140000
SEQUENCE:1571954965
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20191024T150000
URL:https://www.dresden-science-calendar.de/calendar/de/detail/16593
LOCATION:MPI-CBG\, Pfotenhauerstraße 10801307 Dresden
SUMMARY:Seelbinder: Mechanosensitive Chromatin Organization in Cardiac Deve
 lopment and Disease
CLASS:PUBLIC
DESCRIPTION:Speaker: Benjamin Seelbinder\nInstitute of Speaker: University 
 of Colorado Boulder\, USA\nTopics:\n\n Location:\n  Name: MPI-CBG (MPI-CBG
  Galleria)\n  Street: Pfotenhauerstraße 108\n  City: 01307 Dresden\n  Pho
 ne: +49 351 210-0\n  Fax: +49 351 210-2000\nDescription: Environmental mec
 hanical cues are critical to guide cell fate. Particularly in active tissu
 es\, such as the heart\, changes in mechanical properties of the extracell
 ular matrix are associated with cellular dedifferentiation and subsequent 
 functional decline. However\, the underlying mechanoreceptive mechanisms a
 re largely unclear. Recently\, attention has been focused on the nucleus a
 s a potential mechanosensory organelle\, since it is tightly connected to 
 all parts of the cytoskeleton through LINC (linker of nucleo- and cytoskel
 eton) complexes. In addition\, increasing evidence suggests a direct link 
 between nuclear architecture and cell differentiation\, as chromatin organ
 ization changes from an unstructured organization in the zygote to a cell 
 type-specific organization during development. We developed a new method\,
  called deformation microscopy\, which can generate high-resolution strain
  maps from image information. Using this\, we aimed to investigate the nex
 us between cell environments and the integration of mechanical information
  in the nucleus by recording and mapping strain fields in cardiomyocyte nu
 clei during contractions. Overall\, our findings highlight a new role for 
 nuclear mechanosensation in guiding and maintaining cell fate through the 
 reorganization of epigenetically modified chromatin in response to environ
 mental cues.
DTSTAMP:20261102T110829Z
CREATED:20191017T220926Z
LAST-MODIFIED:20191024T220925Z
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