Bi

From cell polarization to cell fusion: What yeast cells can teach us

Datum
23.01.2020
Zeit
11:00 - 12:00
Sprecher
Sophie Martin
Zugehörigkeit
University of Lausanne, Switzerland
Sprache
en
Hauptthema
Biologie
Host
Stephan Grill
Beschreibung
The ability to spatially polarize biochemical activities is a critical property of living systems. How cells self-organize to define a site of polarization that underlies directional migration, division, growth or cell fusion is a question of general interest. To address it, we are using the fission yeast as simple eukaryotic model. Work in unicellular eukaryotes has established that, while most cells polarize in response to a spatial cue, feedback mechanisms in the core cell polarization molecular machinery lead to spontaneously symmetry breaking even in absence of a cue. I will present our recent work centred around the small GTPases Cdc42 and Ras. We used an optogenetic approach to demonstrate positive feedback regulation of Cdc42 in vivo and engineered interactions to reconstruct it and probe its function. Serendipitous observations from this work further revealed membrane flows that pattern the lateral cellular regions around the site of polarity, which we are characterizing through modelling and synthetic approaches. I will further present our work aiming to define how pheromone signalling during sexual reproduction re-wires the polarization machinery to promote cell pairing and fusion.

Letztmalig verändert: 24.01.2020, 00:08:27

Veranstaltungsort

Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG Auditorium (big half))Pfotenhauerstraße10801307Dresden
Telefon
+49 351 210-0
Fax
+49 351 210-2000
E-Mail
MPI-CBG
Homepage
http://www.mpi-cbg.de

Veranstalter

Max Planck Institute of Molecular Cell Biology and GeneticsPfotenhauerstraße10801307Dresden
Telefon
+49 351 210-0
Fax
+49 351 210-2000
E-Mail
MPI-CBG
Homepage
http://www.mpi-cbg.de
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