Bi

How to form a mirror-symmetric organ? Mechanics and signaling in mechanosensory hair cell maturation

Datum
16.05.2019
Zeit
16:00 - 17:00
Sprecher
Anna Erzberger
Zugehörigkeit
Rockerfelly University, N. Y.
Sprache
en
Hauptthema
Biologie
Host
Carl Modes
Beschreibung
Actively regulated symmetry breaking, which is ubiquitous in biological cells, underlies phenomena such as directed cellular movement and morphological polarization. Here we investigate how a unique pattern of cellular polarity emerges during the formation of a mechanosensory organ. Combining theory, genetic perturbations, and in vivo imaging assisted by deep learning, we study the development and regeneration of the fluid-motion sensors in the zebrafish’s lateral line. We find that the combination of two successive symmetry-breaking events — one mediated by biochemical signaling and the other by cellular mechanics — gives rise to a novel form of collective cell migration, which leads to the emergence of a mirror-symmetric polarity pattern in the receptor organ. The morphogenetic principles that we identify underlie the robust regenerative capacity of the organ as well.

Letztmalig verändert: 16.05.2019, 22:09:32 Koordinierte Weltzeit

Veranstaltungsort

Max Planck Institute of Molecular Cell Biology and Genetics (CSBD SR Top Floor)Pfotenhauerstraße10801307Dresden
Telefon
+49 351 210-0
Fax
+49 351 210-2000
E-Mail
MPI-CBG
Homepage
http://www.mpi-cbg.de

Veranstalter

Max Planck Institute of Molecular Cell Biology and GeneticsPfotenhauerstraße10801307Dresden
Telefon
+49 351 210-0
Fax
+49 351 210-2000
E-Mail
MPI-CBG
Homepage
http://www.mpi-cbg.de
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