Bi

Quantification of Nematic Cell Polarity in Three-dimensional Tissues

Datum
16.05.2019
Zeit
14:30 - 16:00
Sprecher
Benjamin M. Friedrich
Zugehörigkeit
Center for Advancing Electronics Dresden, TU Dresden, Germany
Serie
IMB - Seminar
Sprache
en
Hauptthema
Biologie
Host
IMB
Beschreibung
How epithelial cells coordinate their polarity to form complex tissues remains a fundamental question in biology. Here, we characterize a unique type of polarity found in liver tissue - nematic cell polarity, which is different from the common vectorial cell polarity in simple epithelia. We propose a conceptual and algorithmic framework to characterize complex patterns of polarity proteins on the surface of a cell in terms of a multipole expansion. To rigorously quantify previously observed tissue-level patterns of nematic cell polarity (Morales-Navarette et al., bioRxiv:495952, 2018), we introduce the concept of co-orientational order parameters, which generalize the known biaxial order parameters S, P , C, D from the theory of liquid crystals. Applying these concepts to three-dimensional reconstructions of single cells from high-resolution imaging data of mouse liver tissue, we show that the axes of nematic cell polarity of hepatocytes exhibit local coordination and are co-aligned with the biaxially anisotropic sinusoidal network for blood transport. Our study characterizes liver tissue as a biological example of a biaxial liquid crystal. The general methodology developed here could be applied to other tissues or in-vitro organoids.

Letztmalig verändert: 02.05.2019, 08:15:29 Koordinierte Weltzeit

Veranstaltungsort

Institut für Medizinische Informatik und Biometrie (IMB) (Haus 105, Blasewitzer Straße 86, 3rd floor, room 3.465)Blasewitzer Straße8601307Dresden
Homepage
http://tu-dresden.de/die_tu_dresden/fakultaeten/medizinische_fakultaet/inst/imb

Veranstalter

IMBMedizinsche Fakultät Carl Gustav Carus der TU Dresden, Fetscherstr.7401307Dresden
Telefon
+49 351 3177 133
Fax
+49 351 3177 225
E-Mail
IMB
Homepage
http://tu-dresden.de/die_tu_dresden/fakultaeten/medizinische_fakultaet/inst/imb
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