BEGIN:VCALENDAR VERSION:2.0 PRODID:www.dresden-science-calendar.de METHOD:PUBLISH CALSCALE:GREGORIAN X-MICROSOFT-CALSCALE:GREGORIAN X-WR-TIMEZONE:Europe/Berlin BEGIN:VTIMEZONE TZID:Europe/Berlin X-LIC-LOCATION:Europe/Berlin BEGIN:DAYLIGHT TZNAME:CEST TZOFFSETFROM:+0100 TZOFFSETTO:+0200 DTSTART:19810329T030000 RRULE:FREQ=YEARLY;INTERVAL=1;BYMONTH=3;BYDAY=-1SU END:DAYLIGHT BEGIN:STANDARD TZNAME:CET TZOFFSETFROM:+0200 TZOFFSETTO:+0100 DTSTART:19961027T030000 RRULE:FREQ=YEARLY;INTERVAL=1;BYMONTH=10;BYDAY=-1SU END:STANDARD END:VTIMEZONE BEGIN:VEVENT UID:DSC-15812 DTSTART;TZID=Europe/Berlin:20190606T160000 SEQUENCE:1559809537 TRANSP:OPAQUE DTEND;TZID=Europe/Berlin:20190606T170000 URL:https://www.dresden-science-calendar.de/calendar/de/detail/15812 LOCATION:TUD CRTD\, Fetscherstraße 10501307 Dresden SUMMARY:Göritz: CNS Scarring and Repair CLASS:PUBLIC DESCRIPTION:Speaker: Prof. Christian Göritz\nInstitute of Speaker: Karolin ska Institutet Stockholm\, Department of Cell and Molecular Biology\nTopic s:\nBiologie\, Medizin\n Location:\n Name: TUD CRTD (CRTD\, ground floor\ , auditorium left)\n Street: Fetscherstraße 105\n City: 01307 Dresden\n Phone: +49 (0)351 458 82052\n Fax: +49 (0)351 458 82059 \nDescription: Abstract: Damage to the mammalian central nervous system often leads to pe rsistent functional deficits. One important cause why these deficits becom e permanent is the establishment of a scar that blocks regeneration. This seminar will explore the questions of (1.) what the origin and function of scar tissue is and (2.) how different scar components influence axonal re generation and functional recovery after CNS injury. Evidence will be pres ented that (1.) a specific subpopulation of perivascular cells is the main source of stromal scartissue following spinal cord injury. (2.) Pericyte- derived fibrotic cells participate in the wound closure and are crucial fo r the re-establishment of tissue integrity after injury but constitute the long-term persistent fibrotic scar core. (3.) Attenuation of pericyte-der ived scarring improves axonal regeneration and functional recovery. (4.) P ericytes as a new therapeutic target for the treatment of CNS injury. Sel ected publications:* Glutamate transporter Slc1a3 mediates inter-niche ste m cell activation during skin growth. Reichenbach B\, Classon J\, Aida T\, Tanaka K\, Genander M\, Göritz C. EMBO J. 2018 May 2\;37(9). pii: e98280 . * Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cor d Injury. Dias DO\, Kim H\, Holl D\, Werne Solnestam B\, Lundeberg J\, Car lén M\, Göritz C*\, Frisén J. Cell. 2018 Mar 22\;173(1):153-165.e22. *L ead contact author * A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse. Magnusson JP*\, Göritz C*\, Tatarishvil i J\, Dias DO\, Smith EM\, Lindvall O\, Kokaia Z\, Frisén J. Science. 201 4 Oct 10\;346(6206):237-41. *Equal contribution * Resident neural stem c ells restrict tissue damage and neuronal loss after spinal cord injury in mice. Sabelström H\, Stenudd M\, Réu P\, Dias DO\, Elfineh M\, Zdunek S\ , Damberg P\, Göritz C &\; Frisén J. Science. 2013 Nov 1\;342(6158):6 37-40. * A pericyte origin of spinal cord scar tissue. Göritz C\, Dias DO\, Tomilin N\, Barbacid M\, Shupliakov O\, Frisén J. Science. 2011 Jul 8\;333(6039):238-42. DTSTAMP:20260711T094241Z CREATED:20190323T000918Z LAST-MODIFIED:20190606T082537Z END:VEVENT END:VCALENDAR