Regulation of alpha-ketoglutarate dependent dioxygenase TET3 – Novel insights into epigenetic mechanisms in neurons

Datum

30.11.2018

Zeit

15:00 - 16:00

Sprecher

Dr. Stylianos Michalakis Center for Integrated Protein Science Munich CiPSM at the Department of Pharmacy - Center for Drug Research

Zugehörigkeit

Ludwig-Maximilians-Universität München, Munich, Germany

Serie

CMCB Life Sciences Seminar

Sprache

en

Hauptthema

Biologie

Andere Themen

Biologie, Medizin

Host

Dr. Volker Busskamp

Beschreibung

AbstractNeural activity is associated at the epigenetic level with dynamic cytosine methylation and demethylation processes. Demethylation requires enzymatic oxidation of 5 methylcytosine (5mC) to 5 hydroxymethylcytosine (5hmC) and further on to 5-formyl- and 5-carboxycytoside (5fC, 5caC) followed by removal of 5fC and 5caC by base excision repair. The enzymes responsible for these oxidation steps are the alpha-ketoglutarate dependent dioxygenases TET1-3, of which TET3 is the most abundant isoform in neurons. In this presentation, I will show novel data on the functional regulation of TET3 and discuss their relevance for neuronal function. 5 most recent papersM. Wagner, J. Steinbacher, T. F. Kraus, S. Michalakis, B. Hackner, T. Pfaffeneder, A. Perera, M. Müller, A. Giese, H. A. Kretzschmar, T. Carell, Angew Chem Int Ed 2015, 54, 12511-12514.A. Perera, D. Eisen, M. Wagner, S. K. Laube, A. F. Künzel, S. Koch, J. Steinbacher, E. Schulze, V. Splith, N. Mittermeier, M. Müller, M. Biel, T. Carell, S. Michalakis, Cell Rep 2015, 11, 283-294.T. Pfaffeneder, F. Spada, M. Wagner, C. Brandmayr, S. K. Laube, D. Eisen, M. Truss, J. Steinbacher, B. Hackner, O. Kotljarova, D. Schuermann, S. Michalakis, O. Kosmatchev, S. Schiesser, B. Steigenberger, N. Raddaoui, G. Kashiwazaki, U. Müller, C. G. Spruijt, M. Vermeulen, H. Leonhardt, P. Schar, M. Müller, T. Carell, Nat Chem Biol 2014, 10, 574-581S. Koch, V. Sothilingam, M. Garcia Garrido, N. Tanimoto, E. Becirovic, F. Koch, C. Seide, S. C. Beck, M. W. Seeliger, M. Biel, R. Mühlfriedel, S. Michalakis, Hum Mol Genet 2012, 21, 4486-4496.S. Michalakis, R. Mühlfriedel, N. Tanimoto, V. Krishnamoorthy, S. Koch, M. D. Fischer, E. Becirovic, L. Bai, G. Huber, S. C. Beck, E. Fahl, H. Büning, F. Paquet-Durand, X. Zong, T. Gollisch, M. Biel, M. W. Seeliger, Mol Ther 2010, 18, 2057-2063

Links

• to announcement of the organizer

Letztmalig verändert: 30.11.2018, 01:08:58