Evolution of transcription factor networks in primate brains

Datum

24.10.2018

Zeit

11:00 - 12:00

Sprecher

Katja Nowick

Zugehörigkeit

Freie Universität Berlin

Sprache

en

Hauptthema

Biologie

Andere Themen

Biologie, Medizin

Host

Dr. Volker Busskamp

Beschreibung

AbstractOur group studies the evolution of primates. We are interested in the molecular forces that shape phenotypic differences between primate species. I am most fascinated by the differences in brain size and cognitive abilities. Our main focus is on the impact of Gene regulatory factors, such as transcription factors and non-coding RNAs, on differences in transcriptomes, gene regulatory networks, and ultimately the phenotype. We use computational and wet-lab methods to understand the evolution of human specific phenotypes. 5 most recent papersKutsche, L.K., Gysi, D.M.*, Fallmann, J., Lenk, K., Petri, R., Swiersy, A., Klapper, S.D., Pircs, K., Khattak, S., Stadler, P.F., Jakobsson, J., Nowick, K. and Busskamp, V. (2018) Combined experimental and system-level analyses reveal the complex regulatory network of miR-124 during human neurogenesis, Cell Systems in press (*my PhD student is shared first author) Berto, S. and Nowick, K. (2018) Species-specific changes in a primate transcription factor network provide insights into the molecular evolution of the primate prefrontal cortex, Genome Biology and Evolution 2018 Jul 30. doi: 10.1093/gbe/evy149 Berto, S., Perdomo-Sabogal, A., Gerighausen, D., Qin, J., Nowick, K. (2016) A transcription factor consensus network of the human frontal lobe: insights into the molecular mechanisms of human cognitive abilities, Frontiers in Genetics: Special on Systems biology of transcriptional regulation Perdomo-Sabogal, A., Nowick, K.*, Piccini, I., Sudbrak, R., Lehrach, H., Yaspo, ML., Warnatz, HJ.†, Querfurth, R.*† (2016) Human lineage-specific transcriptional regulation through GA binding protein transcription factor alpha (GABPa), Molecular Biology and Evolution 2016 May; 33(5):1231-44. doi: 10.1093/molbev/msw007 (*shared corresponding author) Perdomo-Sabogal, A., Kanton, S., Walter, M.B.C., Nowick, K. (2014) The roles of gene regulatory factors in the history of human evolution, Current Opinion in Genetics and Development 9;29C: 60-67

Links

• to announcement of the organizer

Letztmalig verändert: 23.10.2018, 02:08:25