Mechanisms Controlling the Induction of Reactive Neural Stem Cells in the Hippocampus

Datum

06.09.2018

Zeit

16:00 - 17:00

Sprecher

Prof. Juan Manuel Encinas

Zugehörigkeit

Achucarro Basque Center for Neuroscience, Laboratory of Neural Stem Cells and Neurogenesis

Sprache

en

Hauptthema

Biologie

Andere Themen

Biologie, Medizin

Host

Prof. Federico Calegari

Beschreibung

Abstract My research focuses on the intrinsic properties of the neural stem cells in the adult mammal hippocampus. Their population size, rate of activation and mitotic potential; their activation-coupled astrocytic differentiation and entry into a senescence with aging...all these characteristics determine the true neurogenic potential of each individual organism. Neurological disorders, especially those associated with neuronal hyperactivation, such as epilepsy, profoundly affect neural stem cell properties affecting neurogenesis. For instance, after seizures, neural stem cells transform into reactive astrocytes abandoning their neurogenic program, an unexpected phenomenon which mechanisms we are currently investigating. 5 most important publications Sierra A, Martín-Suárez S, Valcárcel-Martín R, Pascual-Brazo J, Aelvoet SA, Abiega O, Deudero JJ, Brewster AL, Bernales I, Anderson AE, Baekelandt V, Maletić-Savatić M, Encinas JM. Neuronal hyperactivity accelerates depletion of neural stem cells and impairs hippocampal neurogenesis. Cell Stem Cell. 2015 May 7;16(5):488-503. Encinas JM, Michurina TV, Peunova N, Park JH, Tordo J, Peterson DA, Fishell G, Koulakov A, Enikolopov G. Division-coupled astrocytic differentiation and age-related depletion of neural stem cells in the adult hippocampus. Cell Stem Cell. 2011 May 6;8(5):566-79. Sierra A, Encinas JM, Deudero JJ, Chancey JH, Enikolopov G, Overstreet-Wadiche LS, Tsirka SE, Maletic-Savatic M. Microglia shape adult hippocampal neurogenesis through apoptosis-coupled phagocytosis. Cell Stem Cell. 2010 Oct 8;7(4):483-95. Eisch AJ, Cameron HA, Encinas JM, Meltzer LA, Ming GL, Overstreet-Wadiche LS. Adult neurogenesis, mental health, and mental illness: hope or hype? J Neurosci. 2008 Nov 12;28(46):11785-91 Encinas JM, Vaahtokari A, Enikolopov G. Fluoxetine targets early progenitor cells in the adult brain. Proc Natl Acad Sci U S A. 2006 May 23;103(21):8233-8.

Links

• to announcement of the organizer

Letztmalig verändert: 06.09.2018, 02:05:35