Putting craving regulation to the stress test

Datum

24.08.2017

Zeit

16:00 - 17:00

Sprecher

Raoul Dieterich

Zugehörigkeit

TUD, Professur für Suchtforschung

Serie

TUD NIC Kolloquium

Sprache

en

Hauptthema

Psychologie

Andere Themen

Psychologie

Beschreibung

Substance addiction involves persistent drug taking that is prone to relapse despite negative consequences or strong motivation to quit. As treatment approaches currently fail to satisfactorily prevent relapse, identifying mechanisms facilitating abstinence is a promising avenue in guiding successful treatment development. The intensity of craving for drugs is a strong predictor of relapse. It can be induced through substance-related cues and stress, which itself is a significant predictor of relapse. An exciting line of research has demonstrated reductions in cue-induced craving through reappraisal. Successful craving regulation is associated with increased control-related lateral prefrontal and simultaneously reduced craving-related striatal activity, paralleling emotion regulation pathways. However, failing to consider real life demands such as stress, the ecological validity of emotion regulation studies has been challenged, with emotion regulation capacity collapsing after stress induction. As stress impairs prefrontal functions, similar caveats may apply to craving regulation and its potential in relapse prevention, especially as stress elicits craving. The proposed project aims at examining the relationship between stress and craving regulation and its underlying neural correlates in heavy smokers. We hypothesize that a stress-induction (cold pressor test) impairs craving regulation capacity in a regulation of craving task. This should be accompanied by reduced recruitment of the lateral prefrontal cortex and a lack of deactivation in regions comprising the craving circuit.

Links

• Livestream

Letztmalig verändert: 15.08.2017, 16:51:25