Transcriptional implications of mixed lineage leukemia fusion proteins

Datum

22.01.2016

Zeit

11:00 - 12:00

Sprecher

Prof. Robert Slany

Zugehörigkeit

Friedrich-Alexander University Erlangen-Nürnberg, Department of Biology, Division of Genetics

Sprache

en

Hauptthema

Biologie

Andere Themen

Biologie, Medizin

Host

Konstantinos Anastassiadis

Beschreibung

The major topics investigated in our laboratory are:Genetic control of normal and malignant hematopoiesisAberrant chromatin modification by MLL fusion proteins and their role in leukemogenesisBiological function of HOX homeobox genes during differentiation and maturation of hematopoietic cellsPublications:Bach C., and Slany R.K. (2014) DOTting the Path to Doom: How Acceleration of Histone Methylation Leads to Leukemia. Cancer Cell. 8;26(6):781-782.Maethner E., Garcia-Cuellar M.P., Breitinger C., Takacova S., Divoky V., Hess J.L., and Slany R.K. (2013) MLL-ENL inhibits polycomb repressive complex 1 to achieve efficient transformation of hematopoietic cells, CellReports, May 30;3(5):1553-66Breitinger C., Maethner E., Garcia-Cuellar M.P., and Slany R.K. (2012) The homeodomain region controls the phenotype of HOX-induced murine leukemia. Blood, 120(19):4018-4027Müller D., Garcia-Cuellar M.P., Bach C., Buhl S., Mäthner E., and Slany R.K. (2009) Misguided Transcriptional Elongation Causes Mixed Lineage Leukemia, PLOS Biology, 7(11):e1000249Müller D., Bach C., Zeisig D., Garcia-Cuellar M.P., Monroe S., Sreekumar A., Zhou R., Nesvizhskii A., Chinnaiyan A., Hess J.L., and Slany R.K. (2007) A Role for the MLL Fusion Partner ENL in Transcriptional Elongation and Chromatin Modification, Blood, 110: 4445-4454

Links

• to announcement of the organizer

Letztmalig verändert: 22.01.2016, 08:46:04